ICG-COOH applications Indocyanine green ICG-carboxylate Drug delivery Bioimaging Photodynamic therapy Biosensors

ICG-COOH (IndoCyanine Green-Carboxylic Acid) is a compound with fluorescent properties and photo-thermal conversion ability, and is therefore widely used in several applications. The following are the main application fields of ICG-COOH:

Bioimaging: ICG-COOH has strong fluorescent properties with good absorption and emission spectra in the near infrared region (NIR). This makes ICG-COOH an ideal biomarker for bioimaging. For example, in oncology, ICG-COOH can be injected into the body and its distribution and accumulation in tumor tissues can be observed by fluorescent imaging devices. This can be used for early detection of tumors, localization, and assessment of therapeutic efficacy.

Drug delivery: ICG-COOH can play an important role in drug delivery as a carrier of drugs. By binding to drug molecules, ICG-COOH can increase the stability, solubility and targeting of drugs. For example, ICG-COOH can bind to antibodies or peptides targeting tumors to form a targeted drug delivery system that precisely delivers drugs to tumor tissues, improving therapeutic efficacy and reducing side effects.

Photodynamic therapy: ICG-COOH has a photothermal conversion ability and can produce a thermal effect when exposed to light, which is used to destroy tumor cells or treat other diseases. In photodynamic therapy, ICG-COOH is injected into the body and a light source of a specific wavelength is then used to irradiate the tumor area or disease area. The light source activates ICG-COOH to produce a thermal effect, causing the surrounding tumor cells or disease tissue to be destroyed by heat. This treatment has the advantage of selectively killing tumor cells while protecting normal tissue.

Biosensors: ICG-COOH can be used as a biosensor due to its fluorescent properties. By binding to target molecules, ICG-COOH can undergo fluorescent signaling changes and be used to detect and monitor the presence and concentration of specific molecules. For example, ICG-COOH can bind to specific biomarkers for the detection of proteins, drugs or cells in the blood.

In summary, ICG-COOH has a wide range of applications in various fields such as bioimaging, drug delivery, photodynamic therapy and biosensors. Its fluorescent properties and photothermal conversion ability make it a promising biomaterial that can be used to improve diagnostic and therapeutic efficacy.