ICG-Maleimide in neurosurgery ICG-Maleimide ,ICG-MAL CAS2143933-81-5

The application of ICG-MAL in neurosurgery is mainly to help surgeons accurately locate and remove brain tumors, cerebral vascular malformations and other lesions through fluorescence guidance technology. Specific applications include the following aspects:

1. Brain tumor localization and resection: ICG-MAL can bind to tumor-associated molecules, such as tumor antigens or antibodies, by injecting ICG-MAL intravenously into the tumor tissue. Surgeons can then use a fluorescent microscope or other fluorescent imaging equipment to observe the fluorescent signal of ICG-MAL to accurately locate the position and extent of the tumor. This helps the surgeon to accurately remove the tumor during surgery and maximize the preservation of normal tissue. For example, ICG-MAL can bind to tumor antigens and help surgeons achieve precise tumor resection during brain tumor resection surgeries through fluorescence-guided technology.

2. Cerebrovascular malformation treatment: ICG-MAL can be used in the treatment process of cerebrovascular malformations. Cerebral vascular malformation is an abnormality in the structure of blood vessels, which may lead to cerebral hemorrhage or other neurological symptoms. During surgical treatment, surgeons can inject ICG-MAL into the patient's blood vessels and observe the fluorescent signal of ICG-MAL through a fluorescent microscope to help surgeons locate and remove the vascular malformation. For example, ICG-MAL can be combined with tumor-associated vascular markers to assist surgeons in locating and removing abnormal blood vessels during surgery for cerebrovascular malformations through fluorescence-guided technology.

In summary, the application of ICG-MAL in neurosurgery mainly helps surgeons locate and resect brain tumors, cerebral vascular malformations and other lesions through fluorescence guidance technology. It can provide visual guidance during surgery by binding to tumor-related molecules, helping surgeons achieve precise resection operations. In addition, ICG-MAL can be used to study the function and permeability of the blood-brain barrier.