ICG-NH2 in tumor diagnosis and therapy ICG-amine CAS1686147-55-6 Tumor Fluorescence Imaging Therapy Guidance

ICG-NH2 is a derivative of ICG-amine with good fluorescence properties and biocompatibility. In tumor diagnosis and therapy, ICG-NH2 can be used to achieve tumor-specific diagnosis and treatment by binding it to targeting molecules or nanoparticles. Below are several important application areas and corresponding examples of ICG-NH2 in tumor diagnosis and therapy:

1. Tumor Fluorescence Imaging: ICG-NH2 can bind to target molecules for fluorescence imaging and localization of tumors. Researchers can label ICG-NH2 onto antibodies or peptides targeting the surface of tumor cells, and observe the location, size and morphology of tumors through near-infrared fluorescence imaging. For example, in breast cancer research, ICG-NH2 can achieve fluorescent imaging of breast cancer by binding to HER2 antibodies, helping doctors accurately locate and remove tumors.

2. Tumor therapy guidance: ICG-NH2 can be bound to nanoparticles for tumor therapy guidance. Researchers can modify ICG-NH2 onto the surface of nanoparticles, observe the distribution and accumulation of nanoparticles in tumors through near-infrared fluorescence imaging, and realize photothermal therapy through the thermal effect generated by the activation of near-infrared light. For example, in nano-mediated thermotherapy, ICG-NH2 can be modified onto the surface of gold nanorods to kill tumor cells through the thermal effect generated by NIR light activation.

In conclusion, ICG-NH2, as a derivative of ICG-amine, has a wide range of applications in tumor diagnosis and therapy. By combining with targeting molecules or nanoparticles, ICG-NH2 can achieve tumor-specific diagnosis and therapeutic guidance, and improve the efficacy and safety of tumor therapy.