Indocyanine green ICG-amine in drug delivery system ICG-amine CAS1686147-55-6 Targeted delivery Photothermal therapy

ICG-NH2, as a derivative of ICG-amine, has a wide range of applications in drug delivery systems. By modifying ICG-NH2 onto nanoparticles or nanocarriers, the targeted delivery and release of drugs can be achieved, and the bioavailability and therapeutic effect of drugs can be improved. The following are several important application areas and corresponding examples of ICG-NH2 on drug delivery systems:

1. Targeted drug delivery: ICG-NH2 can be modified onto nanoparticles or nanoliposomes for targeted drug delivery. Researchers can encapsulate drugs within nanoparticles or nanoliposomes, and observe the distribution and accumulation of nanoparticles or nanoliposomes on targeted tumor cells through near-infrared fluorescence imaging. For example, in tumor chemotherapy, ICG-NH2 can be modified onto nanoliposomes to encapsulate chemotherapeutic drugs within the liposomes, and the targeted delivery and drug release of the liposomes within the tumor can be observed by NIR fluorescence imaging.

2. Controlled release drug delivery system: ICG-NH2 can be modified onto nanoparticles or nanocarriers for controlled release drug delivery system. Researchers can encapsulate drugs inside nanoparticles or nanocarriers and observe the distribution and release of the nanoparticles or nanocarriers in vivo by near-infrared fluorescence imaging. For example, in tumor therapy, ICG-NH2 can be modified onto nanomicrospheres, the drug can be encapsulated within the microspheres, and the distribution of the microspheres within the tumor and the controlled release of the drug can be observed by the near-infrared fluorescence imaging technique.

3. Photothermal therapy: ICG-NH2 can be modified onto nanoparticles for photothermal therapy. Researchers can observe the distribution and accumulation of nanoparticles in tumors through near-infrared fluorescence imaging, and realize photothermal therapy through the thermal effect generated by the activation of near-infrared light. For example, in nano-mediated photothermal therapy, ICG-NH2 can be modified onto the surface of gold nanorods to kill tumor cells through the thermal effect generated by NIR light activation.

In conclusion, ICG-NH2, as a derivative of ICG-amine, has a wide range of applications in drug delivery systems. By modifying it onto nanoparticles or nanocarriers, ICG-NH2 can achieve targeted delivery and release of drugs, control the release rate and location of drugs, and improve the bioavailability and therapeutic effect of drugs.