Structure and properties of ICG-amine ICG-NH2 CAS1686147-55-6

ICG-amine is a derivative of Indocyanine Green (ICG) with an amine functional group introduced into its structure.The structure of ICG-amine is shown below:

       H3C - N + (CH3)2

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  CH3 -N=C= C -CH= C - N - C=C - C=C- N - C=C - C=N- CH3

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     CH2NH2 CH2CH2OH CH2CH2OH

ICG-amine has several important properties:

1. Fluorescence properties: ICG-amine is an organic dye with good fluorescence properties. It has high absorption and emission peaks in the near infrared wavelength range, usually between 700-900 nm. This allows ICG-amine to absorb and emit light signals efficiently in the transparent window in the organism, reducing the interference of light scattering and absorption.

2. Water solubility: ICG-amine has introduced an amino functional group in its molecular structure, which makes it more water-soluble. This allows ICG-amine to be used in solution form in living organisms, which is convenient for biomedical research and clinical application.

3. Biocompatibility: ICG-amine has good biocompatibility and does not have significant toxicity or side effects on most organisms. This makes ICG-amine safe for use in imaging and therapeutic applications in living organisms.

4. Reactivity: The amino functional group in ICG-amine can react chemically with other compounds, for example with carboxylic acids to form amide bonds. This allows ICG-amine to be used as a precursor for molecular probes, by binding or modifying it to specific molecules for specific applications.

In conclusion, ICG-amine is an indocyanine green derivative with good fluorescence properties, water solubility and biocompatibility. Its structure and properties allow ICG-amine to have a wide range of potential applications in biomedical research and clinical applications.