Product name:

DOPE-PEG-Transferrin

Size :

1g（Specifications can be customized）

Product details:

Use：for research use only.

Appearance：White/off-white pale-yellow solid.
Solvent：DCM、DMF、DMSO、THF etc.
Stability: 12 months at-20℃.

Molecular Weight（PEG）：2000、3400、5000，customizable

Description:

 DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. 

Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

The transferrin receptor (TfR) is a transmembrane glycoprotein whose function is to mediate iron absorption through its interaction with transferrin. In normal cells, the expression level of the receptor is low, and the expression of the transferrin receptor in zhongliu cells (such as lung adenocarcinoma, chronic lymphocytic baixuebing and non-Hodgkin tumor) is significantly increased due to the increased demand for iron in rapidly growing cells [2-4]. 

At present, two transferrin receptors, TfR1 and TfR2, have been found, both of which are type II transmembrane glycoproteins that bind to transferrin and mediate iron absorption. TfR1 is expressed in many cells (such as red blood cells, hepatocytes, monocytes), and can change its conformation according to the change of environmental pH, and convert the results of conformational change into a change in the binding strength of transferrin. 

TfR2 is mainly expressed in the liver, and its main function may be to regulate and maintain the homeostasis of iron ions in the body, while its role in transporting iron ions to rapidly dividing tissues is weak. Using the effective targeting function of transferrin receptor, the cross-linking of transferrin and drugs can improve the specific binding ability of drugs, but also improve the effect.

Note: The products sold by our company are only used for scientific research, not for human experiments or human treatment.

Based on the business model of independent research and development, production and sales integration, the company's products have obvious price advantages compared with similar products on the market. In addition, we also provide professional product customization services.

For other products, please contact us:

Telephone: 023-62795528

Customer service hotline: 

18896157519，QQ: 3354316092

19923757617，QQ：3279537175

17725012670，QQ：3492925539

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