Product Structure:

3beta-[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol

Size :

1g（Specifications can be customized）

Product details:

DC-Chol, also known as 3β-N-(N',N'-dimethylaminoethane) carbamoyl cholesterol, is a cationic lipid commonly used in the formulation of lipid-based delivery systems. Its structure consists of a cholesterol backbone with a carbamoyl group attached to the 3β-position and a dimethylaminoethyl group attached to the carbamoyl group.

 DC-Chol has moderate solubility in water, but it is highly soluble in organic solvents such as chloroform, methanol, and ethanol. This solubility profile allows for easy incorporation of DC-Chol into lipid-based formulations and enables the formation of stable lipid nanoparticles.

 In terms of stability, DC-Chol is relatively stable under normal storage conditions. However, it is susceptible to degradation under acidic or alkaline conditions. Therefore, it is crucial to maintain the pH within a suitable range to ensure the stability of DC-Chol-based formulations.

Description:

DC-Chol, also known as 3β-[N-(N',N'-dimethylaminoethane) carbamoyl] cholesterol, is a cationic lipid commonly used in gene delivery systems. It is composed of a cholesterol backbone with a cationic headgroup attached to it.

DC-Chol possesses unique properties that make it suitable for gene delivery applications. Firstly, its cationic nature allows it to interact with negatively charged nucleic acids, such as DNA or RNA, forming stable complexes called lipoplexes. These lipoplexes facilitate the efficient delivery of genetic material into cells.

Secondly, DC-Chol exhibits good biocompatibility, meaning it is well-tolerated by cells and does not induce significant cytotoxicity. This is crucial for its use in gene therapy, as it ensures the safety of the delivery system.

Furthermore, DC-Chol has the ability to destabilize endosomal membranes, facilitating the release of the delivered genetic material into the cytoplasm. This "proton sponge" effect is caused by the cationic lipid's ability to buffer the acidic pH within endosomes, leading to osmotic swelling and subsequent rupture of the endosomal membrane.

Storage conditions:

Store at - 20 ℃. Avoid frequent thawing and freezing.

Note: The products sold by our company are only used for scientific research, not for human experiments or human treatment.

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