Product Structure:

DMRIE;(3-dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium

Size :

1g（Specifications can be customized）

Product details:

DMRIE (1,2-dimyristyloxypropyl-3-dimethyl-hydroxy ethyl ammonium bromide) is a cationic lipid commonly used in gene delivery systems. It consists of a hydrophilic head group, which contains a tertiary amine and a hydroxyl group, attached to a hydrophobic lipid tail.

In terms of solubility, DMRIE is hydrophobic and insoluble in water. However, it can form stable complexes with nucleic acids such as DNA or RNA, enabling their efficient delivery into cells. These complexes are typically formed by mixing DMRIE with nucleic acids in an aqueous medium, resulting in the formation of lipoplexes.

DMRIE exhibits good stability under physiological conditions. The presence of hydrophobic lipid tails allows it to form stable liposomes or lipoplexes, protecting the encapsulated nucleic acids from degradation. Additionally, the positive charge of the DMRIE head group facilitates its interaction with negatively charged cell membranes, promoting efficient cellular uptake and endosomal escape.

Description:

DMRIE (1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide) is a cationic lipid commonly used in gene delivery systems. It possesses several important properties that make it suitable for this application.

Firstly, DMRIE has a positively charged quaternary ammonium headgroup, which enables it to interact with negatively charged nucleic acids, such as DNA or RNA. This electrostatic interaction promotes the formation of stable complexes, called lipoplexes, between the cationic lipid and the genetic material.

Secondly, DMRIE has a hydrophobic tail composed of two myristoyl chains. This hydrophobic region allows the cationic lipid to insert into and disrupt the lipid bilayer of cell membranes, facilitating the delivery of the nucleic acids into target cells. The hydrophobic tail also contributes to the stability of the lipoplexes by providing a structural support.

Furthermore, DMRIE exhibits good transfection efficiency, meaning it is effective at delivering genetic material into cells. This is attributed to its optimal balance of positive charge and hydrophobicity, which helps to overcome cellular barriers and promote cellular uptake of the lipoplexes.

Storage conditions:

Store at - 20 ℃. Avoid frequent thawing and freezing.

Note: The products sold by our company are only used for scientific research, not for human experiments or human treatment.

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