Cyanine5 for near-infrared imaging Cyanine dye CY5 Tumor/vascular imaging

Cyanine5 (Cy5) has a wide range of applications in near infrared (NIR) imaging. NIR imaging is a non-invasive imaging technique that enables imaging and analysis of biological tissues and cells by detecting fluorescent signals from NIR light. Labeling Cy5 on a target molecule or fluorescent probe enables imaging and quantitative analysis of specific biomolecules, cells or tissues by detecting the near-infrared fluorescent signal of Cy5. The following are applications of Cy5 in NIR imaging:

1. Tumor imaging:

Cy5 can be used in NIR probes for tumor imaging. For example, labeling Cy5 on tumor targeting molecules (e.g., antibodies, peptides, ligands, etc.) generates NIR fluorescent signals by binding to specific targeting molecules on tumor cells. By detecting the near-infrared fluorescent signal of Cy5, localization and analysis of tumors can be achieved. This method can be used in the fields of tumor diagnosis, imaging navigation and drug efficacy assessment. For example, the use of Cy5-labeled antibodies can be used in near-infrared imaging to detect the location and size of tumors.

2. Vascular imaging:

Cy5 can be used in NIR probes for vascular imaging. For example, Cy5 is labeled on vascular targeting molecules (e.g., antibodies, peptides, ligands, etc.) and generates NIR fluorescent signals by binding to specific molecules in the blood vessels. By detecting the near-infrared fluorescent signal of Cy5, imaging and analysis of blood vessels can be achieved. This method can be used in areas such as the detection of vascular lesions and the study of angiogenesis. For example, the use of Cy5-labeled vascular-targeting probes can be used for NIR imaging to detect the morphology and function of tumor blood vessels.

3. Brain imaging:

Cy5 can be used in NIR probes for brain imaging. For example, in neuroscience research, Cy5 is labeled on brain-targeting molecules (e.g., neuronal markers, neurotransmitter receptors, etc.), which generate near-infrared fluorescent signals by binding to specific molecules in the brain. By detecting the near-infrared fluorescent signal of Cy5, imaging and analysis of brain regions and neuronal activities can be achieved. This method can be used in areas such as brain function research and neurological disease diagnosis. For example, the use of Cy5-labeled neuronal markers can be used for near-infrared imaging to detect activity and connectivity in brain regions.

In conclusion, Cy5 has a wide range of applications as a near-infrared fluorescent dye in near-infrared imaging. By labeling Cy5 on targeting molecules or fluorescent probes, near-infrared imaging and quantitative analysis of biological tissues and cells, such as tumors, blood vessels and brain regions, can be achieved. These applications can be used in the fields of tumor diagnosis, vascular lesion detection, and brain function studies, providing an important tool for biomedical research and clinical applications.